专家说可躲避人免疫系统的艾滋病病毒在扩散
2009年02月28日 18:20:36 来源：新华网
新华网东京２月２８日电（记者钱铮）一个国际研究小组在最新一期《自然》杂志上报告说，对８个国家约２８００名艾滋病病毒感染者的分析显示，由于基因变异而能躲避人免疫系统攻击的艾滋病病毒正在扩散。
艾滋病病毒侵入人体后在细胞内反复增殖，导致感染者发病。另一方面，一旦感染了艾滋病病毒，人的免疫细胞就会攻击与人组织相容性抗原结合的艾滋病病毒。在这种作用下，受感染的细胞数量会减少，但是不能完全被排除。
日本熊本大学研究人员参与的这个国际小组由此推测，是不是艾滋病病毒发生了变异，因此能躲过人免疫系统的攻击。研究人员对日本、英国、南非等８个国家约２８００名艾滋病病毒感染者进行了分析，他们发现与人组织相容性抗原结合的艾滋病病毒的蛋白质共有１４处发生了变异。另外，有一些感染者先天拥有某种特定类型的人组织相容性抗原，他们当中约９６％的感染者的细胞内测出了变异的艾滋病病毒，而不具备这种特定抗原的感染者中也有２９％的人体内存在变异的艾滋病病毒。
研究人员推测，在拥有上述特定类型抗原的感染者体内，变异的艾滋病病毒不断增殖，并通过性接触等途径散播到不具备这种特定抗原的人体内。
据推算，迄今艾滋病已经夺走了约２５００万人的生命，目前全球还有３３００万名艾滋病病毒感染者。针对艾滋病病毒的疫苗还未达到实用水平，艾滋病防控形势面临严峻考验。参加上述研究的科研人员指出，目前开发疫苗所使用的艾滋病病毒还属于约２０年前发现的类型，这项新研究成果说明，有必要尽快改变艾滋病病毒疫苗开发的现行战略。
Experts say people can evade the immune system at the spread of HIV
February 28, 2009 18:20:36 Source: Xinhuanet
Xinhua Tokyo, February 28 (Xinhua Qian Zheng), an international research team in the latest issue of "Nature" magazine reported that the country of about 8 to 2800 HIV-infected persons analysis shows that because of genetic mutation and can avoid Human immune system to attack the AIDS virus is spreading.
AIDS virus invaded the human body repeatedly in the cell proliferation, resulting in infection incidence. On the other hand, once infected with HIV, the human immune cells will attack and Human histocompatibility antigen-binding HIV. In this role, the quantity of infected cells will be reduced, but should not be excluded completely.
Japan Kumamoto University researchers involved in this international team thus speculated that happen are not the variability of HIV, so people can escape the immune system attacks. Researchers to Japan, the United Kingdom and South Africa about eight National 2800 HIV-infected persons were analyzed, they found that with people histocompatibility antigen-binding proteins of HIV occurred in a total of 14 variations. In addition, some infected people have some innate specific type of person histocompatibility antigen, some of whom about 96% of the infected cells least one out of HIV variation, and not have this specific antigen in the infected also has 29% of the human body exists in the variation of HIV.
The researchers speculated that having the above-mentioned types of antigen-specific infection in vivo, variation of constant proliferation of HIV through sexual contact, such as ways to spread that does not have this specific antigen in human bodies.
It is estimated that AIDS has so far claimed about 25 million people's lives around the world there are 33 million HIV-infected persons. Vaccines against HIV have not yet reached the practical level, AIDS prevention and control of the situation facing a severe test. Take part in the above study researchers pointed out that the current vaccine used in the development of HIV also belong to about 20 years ago found that the type, this new research shows that there is a need to change as soon as possible HIV vaccine development strategy of the current.
February 28, 2009 18:20:36 Source: Xinhuanet
Xinhua Tokyo, February 28 (Xinhua Qian Zheng), an international research team in the latest issue of "Nature" magazine reported that the country of about 8 to 2800 HIV-infected persons analysis shows that because of genetic mutation and can avoid Human immune system to attack the AIDS virus is spreading.
AIDS virus invaded the human body repeatedly in the cell proliferation, resulting in infection incidence. On the other hand, once infected with HIV, the human immune cells will attack and Human histocompatibility antigen-binding HIV. In this role, the quantity of infected cells will be reduced, but should not be excluded completely.
Japan Kumamoto University researchers involved in this international team thus speculated that happen are not the variability of HIV, so people can escape the immune system attacks. Researchers to Japan, the United Kingdom and South Africa about eight National 2800 HIV-infected persons were analyzed, they found that with people histocompatibility antigen-binding proteins of HIV occurred in a total of 14 variations. In addition, some infected people have some innate specific type of person histocompatibility antigen, some of whom about 96% of the infected cells least one out of HIV variation, and not have this specific antigen in the infected also has 29% of the human body exists in the variation of HIV.
The researchers speculated that having the above-mentioned types of antigen-specific infection in vivo, variation of constant proliferation of HIV through sexual contact, such as ways to spread that does not have this specific antigen in human bodies.
It is estimated that AIDS has so far claimed about 25 million people's lives around the world there are 33 million HIV-infected persons. Vaccines against HIV have not yet reached the practical level, AIDS prevention and control of the situation facing a severe test. Take part in the above study researchers pointed out that the current vaccine used in the development of HIV also belong to about 20 years ago found that the type, this new research shows that there is a need to change as soon as possible HIV vaccine development strategy of the current.