|
生殖器疱疹患者易感染艾滋
http://www.qianlong.com/2010-11-08 09:13:03千龙网
 |
| 图示∶2010年12月即将出版的《中国特色医疗金鉴》登载的刘君主任及其机构 |
| |
|
|
男性生殖器疱疹症状：生殖器疱疹HSV感染后平均约4～5日，外阴患部先有灼热感，旋即发生成群丘疹，可为一簇或多簇，继之形成水疱。数日后演变为脓疱，破溃后形成糜烂或浅溃疡，自觉疼痛，最后结痂自愈，病程约2～3周。皮损多发于男性的包皮、龟头、冠状沟和阴茎等处，偶见于尿道口；女性则多见于大小阴唇、阴蒂、阴阜、子宫颈等处，亦见于尿道口。
原发性生殖器疱疹，往往伴有全身不适，低热、头痛等全身症状，局部淋巴结肿大。本病常复发，复发性生殖器疱疹较原发者轻，损害小，往往无全身症状。男性同性恋可出现肛门直肠HSV-2感染，其发病率仅次于淋球菌所致的肛门直肠炎，临床表现为肛门直肠疼痛、便秘、分泌物增加和里急后重，肛周可有疱疹性溃疡，乙状结肠镜检常见直肠下段粘膜充血、出血和溃疡。
生殖器疱疹和艾滋病具有密切的关系，两者相互影响，相互促进。大量的流行病学研究以及证实，生殖器疱疹病人中的艾滋病感染的危险性增加2-10倍。同时，临床研究也表明，生殖器疱疹和艾滋病合并感染后，临床特征也可能出现明显改变。那么，生殖器疱疹病人为什么容易感染艾滋病呢？
从病原体生物学的角度来看，病原体的感染和生殖器疱疹的发病为艾滋病病毒进入机体创造了合适的条件。
艾滋病病毒要进入人体，需要一定的条件。病毒要经过破损的皮肤和粘膜，甚至肉眼不容易察觉的细微损伤部位进入人体，并吸附到局部的靶细胞中，在靶细胞中大量复制和繁殖，进而播散至全身各个器官和系统。
在人体中，艾滋病病毒攻击的靶细胞主要是CD4阳性的T淋巴细胞，这种细胞广泛分布在人体组织液和血液中，并积极地参与人体的炎症反应和免疫反应。由于感染的存在，即使这种感染的症状轻微，甚至未被察觉，其感染局部也会出现明显的炎症反应和免疫反应，CD4阳性细胞在泌尿生殖道炎症局部的聚集也增加。
Genital herpes infection in HIV patients tend to
http://www.qianlong.com/2010-11-08 09:13:03 Qianlong
Male genital herpes symptoms: Genital herpes HSV infection on average about 4 to 5 days, the affected area first, vulva burning, immediately papules occur in groups, for a cluster or clusters, followed by the formation of blisters. A few days later evolved into pustules, erosion or rupture to form shallow ulcers, perceived pain, and finally scar healing, duration of about 2 to 3 weeks. Multiple lesions of the male foreskin, glans, Coronal and penis, etc., occasionally in the urethra; women prevalent in the size of the labia, clitoris, mons pubis, the cervix, etc., are also found in the urethra.
Primary genital herpes, often accompanied by general malaise, fever, headache and other systemic symptoms, local lymph nodes. Regular recurrence of the disease, recurrent genital herpes were more primary light, damage is small, usually no systemic symptoms. Gay men can appear anorectal HSV-2 infection, the incidence rate of anal proctitis caused by Neisseria gonorrhoeae after the clinical pattern of anorectal pain, constipation, increased secretions, and tenesmus, perianal ulcers may have herpes, sigmoid colon lower rectal examination common mucosal hyperemia, hemorrhage and ulcers.
Genital herpes and AIDS has a close relationship, the two interact and promote each other. A large number of epidemiological studies and confirmed that genital herpes infection in AIDS patients with increased risk of 2-10 times. Meanwhile, clinical studies have shown that genital herpes and HIV co-infection, the clinical features of significant changes may also occur. So, why the risk of contracting genital herpes, AIDS patients do?
From the perspective of biological pathogens, pathogen infection and incidence of genital herpes for the AIDS virus into the body to create the right conditions.
AIDS virus to enter the human body, requires certain conditions. Virus to go through broken skin and mucous membranes, and even the naked eye is not easy to detect subtle injury site into the human body, and adsorption to the local target cells, target cells in a large number of replication and reproduction, and then spread to various body organs and systems.
In the human body, HIV attacks CD4 positive target cells are mainly T-lymphocytes, these cells are widely distributed in human tissue fluid and blood, and actively participate in the body's inflammatory response and immune response. Because the presence of infection, even if mild symptoms of infection, or even undetected, the infection will be significant local inflammation and immune responses, CD4 positive cells in the urinary genital tract inflammation local accumulation also increased.
|
