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呼吁救治艾滋，关注化学新药
记康生丹四代新药—三合皂甙发明人刘君
三种化学有效单体成分均对HIV有明显抑制、杀灭作用；科学的组合三种皂甙〔也称皂素〕，实验与临床均显示对于艾滋病神气的控制疗效；所有试用三合皂甙的患者轻重不同的症状约在1～3月内迅速消失，HIV病毒载量检测基本接近LPD〔检测不到或很少量〕，CD4也在大约6～12个月左右相续恢复700～1500个/微升。
新药的主要成分3种皂素，药理机理作用于T细胞并促使免疫细胞产生免疫记忆；机体感染HIV后，病毒整合于T细胞等免疫细胞，阻断并变异细胞编译基因，携带阴藏的HIV基因片段，在潜伏后因细胞记忆功能的作用诱导下，加之外界刺激促使免疫力急速下降时，将诱导产生大量繁殖或扩散。常规的蛋白酶抑制剂或抗病毒的鸡尾酒药，只是通过蛋白酶作用于HIV病毒的包膜，穿透包膜，阻断HIV合成代谢继续，而杀死HIV；在杀死病毒的同时，也杀死了HIV寄主的T细胞等免疫细胞，使人体免疫力短期急剧邹降，各种严重的并发症随之出现。这个时候，常规治疗根本没有任何作用；因为免疫已经被损伤到严重的无代偿阶段，机体应答反应漠视，病毒疯狂复制、繁殖。以上也就是鸡尾酒疗法为什么使用一段时间后突然出现很严重的并发症或副反应的根本原因。
为了彻底解决艾滋病病因病理对于人体的损伤，探索T细胞与CD4、HIV与T细胞、HIV与CD4，三者之间的病理机制，模型设置探索其药理机制，17年以来是刘君医师科研组的主要攻关任务。研究证明∶当机体T细胞属于正常范围时，CD4也属于正常范围，HIV稳定不复制或下降明显；当机体HIV病毒载量相当高时，机体T细胞严重减少，CD4也崩溃到边缘水平。当CD4上升到一定水平后，机体T细胞也随之上升，并相互呈正比；相反，当机体T细胞检测很高时，机体内测定HIV载量也很低或测不到。
科研组长期探索于T细胞→CD4→HIV三者的临床与实验，将有效提取三种植物的化学单体组合新药—三合皂甙〔康生丹四代，是在一代、二代、三代基础上最新研制〕试用患者与受试动物模型，观测得到T细胞调控利于HIV的有效根本降低并复制不反复、CD4提升制约HIV扩散或扩殖，证实三合皂甙高效可靠的根治HIV的机理。
发明人刘君透露∶从食品植物中研究开发的治疗艾滋病新药康生丹〔暂定名，化学名∶三合皂甙〕，由三种皂甙科学组合而成。
皂苷又名皂甙或皂素，是固醇类或三萜类化合物的低聚配糖体总称，因其水溶液能形成持久泡沫，象肥皂一样而得名，它广泛存在于植物和海洋动物体内。
以上化学成份主要药理作用∶1。增强免疫调节功能。对T细胞具有增强作用，特别是T细胞功能的增强，可以使IL一2(白介素)的分泌提高，而IL一2的功能可以保护T细胞的存活与繁殖。促进T细胞产生淋巴因子，增强诱杀性细胞NK(自然杀伤性细胞)的分化。提高LAK(淋巴因子激活的杀伤性细胞)的活性，从而生物体表现出较强的免疫功能。2。抗肿瘤作用。①对肿瘤细胞有直接毒杀作用和生长抑制作用。②与胆汁酸相结合可以形成较大的混合微团，从而防止结肠癌的发生。③防止上皮细胞增生，使增生细胞正常化，从而起到杀伤肿瘤细胞的作用。3。抗病毒抗HIV作用。主要研究证明可以生物性抑制HIV毒斑的形成，使细胞免疫得到无序保护，进而杀灭HIV。4。抗氧化、抗自由基与抗凝血、抗血栓、抗糖尿病等。通过增加SOD (超氧化物歧化酶)的含量，降低LPO(过氧化脂质)，清除自由基，减轻自由基的损害作用，促进修复。可以降低x射线诱发遗传物质损伤的机率，可以通过减少辐射水解产物一自由基，加速自由基的代谢而起间接作用，LPO是自由基代谢产物。可以抑制血小板凝聚，并使血纤维蛋白减少，还可以抑制体内毒索引起纤维蛋白的凝聚作用，并可以抑制凝血酶引起的血栓纤维蛋白的形成。可以抑制纤维蛋白原向纤维蛋白转化，可降低血糖，血小板的凝聚率，有抗糖尿病的功效。
皂甙(saponins)又称皂素，是广泛存在于植物界的一类特殊的甙类，它的水溶液振摇后可生产持久的肥皂样的泡沫，因而得名。根据皂甙水解后生成皂甙元的结构，可分为三萜皂甙(triterpenoidal saponins)与甾体皂甙(steroidal saponins)两大类。组成皂甙的糖常见的有葡萄糖、半乳糖、鼠李糖、阿拉伯糖、木糖及葡萄糖醛酸、半乳糖醛酸等，常与皂甙元C3位的-OH连接成甙。皂甙的药理作用∶1. 双向调节免疫作用；2. 抗缺氧和抗疲劳作用；3. 抗低温应激作用；4. 抗脂质氧化作用；5. 对中枢神经系统的作用；6. 抗致突变作用；7. 对肾有调节作用，补肾。 
康生丹四代新药—三合皂甙样品
“艾滋病28年来的发现、研究与治疗，从鸡尾酒到联合治疗，T细胞免疫重建意义重大；担负着挽救生命、保障健康与生存延长的重大使命。”康生丹四代Ⅱ类新药—三合皂甙发明人刘君先生如此感慨地告诉人们。
最早提出免疫应答反应重启免疫，将CD4与T细胞纳入艾滋病治疗、研究与临床的统计进行科学的研究工作的，是康生丹2000年1月6日申报中国新药发明专利时的情景。
康生丹做为刘君研究艾滋病成果被提出并被媒体关注是2003年的事情，距今已六年有余。康生丹从最初的一代、二代到三代—康生丹颗粒，以及新推出的四代化学二类新药—三合皂甙；经历了千辛万苦的探索，逐步探明化学有效成分—三种皂甙，对于HIV病毒及其并发症等从免疫应答入手重组免疫，无序保护T细胞，生物性抑制人类免疫缺陷病毒毒斑的形，进而杀灭HIV；有效科学的防治AIDS。呼吁相关行业关注并能积极支持此项研究尽早造福人类、造福患者、造福社会。
Call for treatment of HIV, concern about the chemistry of new drugs
Kang Sheng dan mind four generations of new drugs - saponin三合inventor Liu
Monomer composition of the three chemicals were effective against HIV have significantly inhibited, kill; scientific combination of three saponins, also known as saponin 〔〕, experimental and clinical AIDS have shown that the efficacy of air control; all trial patients saponins Sanhe the severity of different symptoms in about 1 ~ 3 months is fast disappearing, HIV viral load testing close to or less than detection LPD 〔〕 little, CD4 is also about 6 to 12 months with continued restoration of about 700 ~ 1500 / Micro or.
The main components of new drugs three kinds of saponin, pharmacological mechanism of the role of the T cells and immune cells to generate immune memory; the body after HIV infection, the virus integrated into the immune cells such as T cells, blocking and compiler variant cell genes, carrying the HIV negative possession gene fragments, in the potential due to the function of memory cells induced, in addition to external stimuli to the rapid decline in immunity, it will be a large number of breeding or induced proliferation. Protease inhibitors or conventional anti-viral drug cocktails, but the role of protease in the HIV envelope viruses, envelope penetration, blocking HIV anabolic continue, and to kill HIV; in killing the virus also killed the HIV host immune cells such as T cells, so that the human immunodeficiency Zou sharply lower short-term, a variety of serious complications resulting. This time, conventional treatment did not have any effect; because immunization has been no serious injury to the compensatory phase, disregard body response, viral replication crazy, reproduction. More than the cocktail that is why the use of the sudden appearance after a period of very serious side effects or complications of the underlying causes.
In order to solve the AIDS cause pathological damage to the human body to explore the T cells and CD4, HIV and T cells, HIV with CD4, the pathological mechanisms between the model set up to explore its pharmacological mechanism is 17 years since the research group of Dr. Liu The main research task. Research proves: When T cells are the body when the normal range, CD4 is also a normal range, HIV replication is not stable or decrease significantly; when the body HIV viral load is very high, the body was severely reduced T cells, CD4 is also the level of collapse-to-edge. When the CD4 increased to a certain level, the body also increased by T cells and was directly proportional to each other; the contrary, when the body detect high T cells, the local determination of HIV load in vivo is very low or less than measured.
Research group to explore the long-term T cell → CD4 → HIV among clinical and experimental, will be effective the chemical plant extract three monomer combinations of new drugs - saponin三合〔Dan Kang Sheng four generations, is in the generation, second generation, three generations based on the 〕 trial in patients with newly developed animal model and the subjects were observed to be conducive to T cell regulation and control of HIV replication effectively and not simply to reduce repeated, CD4 enhance HIV proliferation or expansion constraints yield confirmed saponins三合radical highly efficient and reliable mechanism of HIV.
Liu said the inventor: food plants from the research and development of new drugs to treat AIDS Kang Sheng Dan 〔tentative name, chemical name: Sanhe〕 saponins from three scientific combination of saponin.
Saponins, also known as saponin or saponin is a steroid or triterpenoid compounds collectively oligosaccharide glycosides, which in aqueous solution to form a durable foam, the same name as the soap, it widely exists in plants and marine animals.
More than the chemical composition of the major pharmacological effects: 1. Immune regulatory function. To enhance the role of T cells, in particular, the enhanced T cell function, can make IL-2 (IL-) secretion to increase, while the function of IL-2 can protect the T cell survival and reproduction. The promotion of T cells to produce lymphokines, and enhance cell Traps NK (natural killer cell) differentiation. Enhance the LAK (lymphokine-activated killer cells) activity, and thus organisms showed strong immune function. 2. Anti-tumor effects. ① to kill tumor cells have a direct role and growth inhibition. ② combination with the bile acid can form large mixed micelles, thereby preventing the occurrence of colon cancer. ③ to prevent the proliferation of epithelial cells, so that the normalization of proliferative cells, which play the role of anti-tumor cells. 3. Anti-virus anti-HIV effect. Biological research can prove that inhibition of plaque formation of HIV drugs, so that the protection of cellular immunity has been disorderly, and then kill HIV. 4. Anti-oxidation, anti-free radical and anti-coagulation, anti-thrombotic, anti-diabetes. By increasing the SOD (superoxide dismutase) content, reducing LPO (LPO), scavenging free radicals and reduce the role of free radical damage and promote repair. Can reduce the x-ray-induced damage probability of genetic material, can reduce the radiation of a hydrolysis product of free radicals, accelerate the metabolism of free radicals into the indirect effects, LPO is a free radical metabolites. Can inhibit platelet aggregation, and reduce fibrin, but also can inhibit the in vivo toxicity index of cohesion from the role of fibrin, and can inhibit thrombin-induced fibrin thrombus formation. Can inhibit fibrinogen conversion to fibrin, can reduce blood sugar, the rate of platelet cohesion, there are anti-diabetic effect.
Saponins (saponins), also known as saponin, is widely present in plants of a special class of glycosides, and its aqueous solution can produce long-lasting after振摇soap bubble-like, hence the name. After hydrolysis in accordance with saponin Sapogenins generated structure can be divided into triterpenoid saponins (triterpenoidal saponins) and steroidal saponins (steroidal saponins) two broad categories. Saponin composition of common sugar glucose, galactose, rhamnose, arabinose, xylose and glucuronic acid, galacturonic acid, etc., are often associated with C3 Sapogenins-OH-bit connection into effect. Pharmacological effects of saponins: 1. Immunoregulatory role of two-way; 2. Anti-hypoxia and anti-fatigue effect; 3. The role of anti-low-temperature stress; 4. Anti-lipid peroxidation; 5. The role of the central nervous system; 6. Anti - mutagenesis; 7. the adjustment of the kidney, kidney.
Dan Kang Sheng four generations of new drugs - saponin三合samples
"AIDS 28 years ago the discovery, research and treatment, from cocktails to the combination therapy, T cell immune reconstitution of great significance; charged with saving lives, protect the health and survival of a major extension of the mission." Kang Sheng Dan Ⅱ type of four generations of new drugs - San saponin Mr. Liu Jun inventor with emotion to tell people so.
The first reaction of the immune response to the resumption of immunization, CD4 and T cells will be included in AIDS treatment, research and clinical statistics of scientific research work is Dan Kang Sheng January 6, 2000 declaration of the Chinese drug scene at the time of invention patents.
Kang Sheng Liu Dan as the outcome of AIDS research and media attention has been raised is the matter in 2003, more than six years ago. Kang Sheng Dan from the first generation, second generation to third-generation - Kang Sheng Dan particles, as well as the new fourth generation of chemical second-class drugs - saponin三合; experienced a lot of hard work exploration, and gradually found the chemical active ingredients - three types of saponin for the HIV virus and its complications, such as starting with the reorganization of the immune response from immunization, the protection of T cell disorder, biological inhibition of human immunodeficiency virus drug-shaped plaques, which kill HIV; effective prevention science AIDS. Call for attention to related industries and actively supported this study the benefit of mankind as soon as possible to benefit patients, benefit of the community.
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