转基因烟草可制抗艾滋病药物
http://www.sina.com.cn 2009年09月24日 08:08 科技日报
本报柏林9月22日电(记者顾钢)德国研究人员最近开发出一种新的生产工艺，利用转基因烟草生产抗艾滋病病毒药物，这项工艺可以大大降低生产抗艾滋病病毒药物的成本。
目前抗艾滋病病毒抗体都是通过从动物细胞中提取，这不仅费时费力，而且成本很高。在欧盟资助的一个针对艾滋病的专项研究中，研究人员成功地从转基因烟草中获取了防艾滋病病毒抗体2G12，这种抗体与病毒表面的蛋白质结合后，可以阻止病毒进一步侵入人体的免疫细胞。
从转基因烟草中提取抗体，可以极大地降低抗艾滋病药物的成本，这个专项研究由欧盟国家的39个研究机构和企业共同参与。
德国弗劳恩霍夫分子生物和生态应用研究所在这个专项中承担了开发生产工艺的重要任务。研究人员首先将收获后的转基因烟草洗净和切碎，然后用萃取的方法，并通过多级过滤和层析法获得所要的药物成分。为此，研究人员还开发出了有4道工序的生产试验装置。经过不断的工艺完善，该研究所的这一中试生产装置在今年8月获得了GMP药品生产质量资格证书，每周可生产1000公斤植物型抗艾滋病药物。
艾滋病是传播很广和危害极大，迄今还没有完全被攻克的疾病，目前的抗艾滋病药物价格昂贵，许多发展中国家的艾滋病患者都承受不起。植物型抗艾滋病药物的成功开发，对治疗艾滋病药物的普及具有重要意义。
Transgenic tobacco can be prepared anti-AIDS drugs
http://www.sina.com.cn 2009 Nian 09 Yue 24 Ri 08:08 Science and Technology Daily
Newspaper in Berlin September 22 (Xinhua Steel) German researchers have recently developed a new production technology, the use of genetically modified tobacco-producing anti-HIV drugs, the process can greatly reduce the production cost of anti-HIV drugs.
Currently anti-HIV antibodies are extracted from the animal cells is not only laborious and costly.在欧盟资助的一个针对艾滋病的专项研究中，研究人员成功地从转基因烟草中获取了防艾滋病病毒抗体2G12，这种抗体与病毒表面的蛋白质结合后，可以阻止病毒进一步侵入人体的免疫细胞。
Extracted from transgenic tobacco antibody, can greatly reduce the cost of anti-AIDS drugs, this special study was funded by the European Union countries, 39 research institutes and enterprises to participate.
Germany's Fraunhofer Institute of Applied molecular biology and ecology of this special commitment to the development in the important task of the production process. The researchers first harvest of genetically modified tobacco washed and chopped, and then use the method of extraction, and through multi-stage filtration chromatography to obtain the desired drug ingredients. Do, the researchers also developed with four production lines experiments. After continuous craft perfected this in the Institute's pilot production plant in August this year, won the GMP pharmaceutical manufacturing quality certification, a week can produce 1,000 kilograms of plant-based anti-AIDS drugs.
AIDS is spread very widely, and have done great harm had not yet completely overcome the disease, the current anti-AIDS drugs are expensive, many developing countries are living with AIDS can not afford. The success of plant-based anti-AIDS drug development, the popularity of the treatment of AIDS drugs of great significance.
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