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艾滋病治疗取得突破性进展
2011/1/1/20:50来源：高校学报
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| 图示∶2010年12月即将出版的《中国特色医疗金鉴》登载的刘君主任及其机构 |
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蒂莫西·雷·布朗(Timothy Ray Brown)一定是2010年最引人注目的病人。
有关他的一切都神秘极了，很少有人知道他头发的颜色，家里养着什么宠物，或是喜欢哪个电影明星。尽管如此，全世界的媒体都在争相报道这个居住在德国柏林的42岁白人男子。他曾经被艾滋病纠缠了整整10年。12月8日，一个由德国三所大学医学部研究人员组成的七人小组在著名科学杂志《血液》上发表在线论文称，“我们的研究结果证明这个病人的艾滋病被治愈了”。
自从1981年艾滋病毒被发现后，在这个“世纪杀手”多达6000万人的追杀名单中，布朗也许是第一个也是目前唯一一个被治愈的人。这名德国病人的痊愈被视为“令人震撼的突破性进展”。
治疗白血病时治愈了艾滋病
奇迹发生在一栋砖红色的建筑里，那是位于德国首都的夏洛特医院，也是欧洲规模最大的大学医院。
布朗是这家医院的老病号了。自从10年前被诊断出患有艾滋病后，他就一直在这里接受药物治疗。病毒没有击垮这个中年男人的身体，而是一直在他体内平静地潜伏着。
在清华大学艾滋病综合研究中心教授张林琦看来，这正是艾滋病毒可怕的地方。如果将细胞看成一座金库，这种病毒就像是一个劫匪。这个在显微镜下看来就像是个“小刺球”的病毒，会破解“金库”大门的“安全密码”，冲进细胞内部。然后，它会将自己的印记整合进细胞最内部的染色体，变成细胞的一部分。
如今，人们对这个抢劫者带来的危险已经不再陌生，它会攻击人体免疫系统中最重要的T4淋巴组织。一旦免疫组织崩溃，人的抵抗能力变低，就极有可能因感染死亡。
抢劫者可能在病人体内潜伏10年以上。因此，当人们将药物“警察”派入被感染的病人体内时，也往往难以追捕到这些悄悄隐藏的坏蛋。
布朗就一直生活在这群劫匪的阴影之下。同时，另外一种可怕的疾病又悄悄地缠上了他。几年前，这个倒霉的男人确诊患有白血病。在两种“绝症”的夹击之下，看起来，他几乎失去了生存下去的可能。
不过，夏洛特医院临床医生主任埃克哈德·蒂尔(Eckhard T hiel)并没有放弃，这个主攻血液学和肿瘤学的医生决定进行一个大胆的尝试。在上个世纪90年代中期，美国的一些科学家曾经发现，有一些人天生不会受到艾滋病毒的感染。蒂尔和他的同事们开始思考，如果在与布朗骨髓配型的捐献者中找到一个“天生不受艾滋病毒感染者”，“在用骨髓移植治疗白血病后，是不是病人体内的艾滋病毒也会跟着一起消失呢”？
事实上，在普通人的细胞“金库”外，大多设置了两个“安全密码”，一个被称作CD4，另外一个则被称作CCR5。但对艾滋病毒来说，这两组密码破解起来非常容易，所谓的安保措施形同虚设。
但在那些天生对艾滋病毒“免疫”的幸运儿细胞上，由于基因突变，CCR5基因编码区域第185号氨基酸后发生了32碱基缺失。这种被称为CCR5△32的缺陷型基因就相当于为金库加密，劫匪无论使出怎样的招数，都无法溜到金库之中。
A breakthrough in AIDS treatment
2011/1/1/20: 50 Source: Universities
Timothy West Brown (Timothy Ray Brown) must be the most compelling of 2010 patients.
Everything about him was very mysterious, very few people know his hair color, home reared any pets, or like what a movie star. Nevertheless, the world's media are rushing to report on the living in Berlin, Germany, 42-year-old white man. He has been entangled for a whole 10 years of AIDS. December 8, a German study of three Department of Medicine, University of the composition of the seven-member scientific journal in the famous "blood," published online papers said, "Our results show that this patient has been cured of AIDS."
Since 1981 HIV was discovered, in this "century killer" as many as 6,000 people to kill list, Brown is perhaps the first and the only one who has been cured. The German patient's recovery was regarded as "a stunning breakthrough."
Treatment of leukemia cure AIDS
Miracles take place in a red brick building, it is the capital of the Charlotte hospital in Germany and Europe's largest university hospital.
Brown is old and sick, this hospital has. Since 10 years ago was diagnosed with AIDS, he has been receiving medical treatment here. Virus does not defeat the middle-aged man's body, but has been quietly lurking in his body.
AIDS Research Center at Tsinghua University, Professor Zhang Linqi it, this place is terrible HIV. If the cell as a vault, the virus is like a robber. This seems like under the microscope is a "small thorn ball" of the virus, it will break the "vault" door "security code", rushed into the cell interior. Then, it will mark their integration into the chromosomes within the cell the most, become a part of cells.
Today, the people, bringing the risk of robbery is no longer strange, it will attack the body's immune system is the most important T4 lymphoid tissue. Once the collapse of the immune tissue, the human resistance to change is low, most likely to die due to infection.
Robbery may lurk in a patient over 10 years. Therefore, when people drug "police" sent into the body of infected patients, they are often difficult to hunt down bad guys in these quietly hidden.
Brown has been living in the shadow of these robbers. Meanwhile, the other a terrible disease and wrap him quietly. A few years ago, the hapless man diagnosed with leukemia. In both "incurable disease" under the attack, it seems, he almost lost the possibility of survival.
However, hospital clinicians, director Charlotte Eckhard Mohamad (Eckhard T hiel) did not give up, the main medical hematology and oncology decision to conduct a bold attempt. In the mid-90s last century, some U.S. scientists have found that some people will not be born with HIV infection. Steele and his colleagues began to think, if equipped with the Brown-type donor bone marrow to find a "born free from HIV," "in the treatment of leukemia with bone marrow transplantation, the patient is HIV in the body will disappear along with it? "
In fact, in ordinary people's cell "treasury", most of the set of two "secure password", one was called CD4, another were called CCR5. But for HIV, it is very easy password cracking groups, the so-called security measures useless.
But in those born to HIV "immune" cells of the lucky ones, due to gene mutation, CCR5 gene coding region after amino acid No. 185 of 32 base deletion. This is known as CCR5 △ 32 of the defective gene is equivalent encryption for the vault, the robbers no matter what the tricks resorted to, can not sneak into treasury.
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