AIDS research scientists make a breakthrough the first time in the process of filming to the spread of HIV

At 9:57 on March 30, 2009 Source: "Technology Daily"
 

Recently, the United States the first time scientists have taken to the HIV spread in the human body, they found HIV virus in a previously unknown transfer from infected cells to healthy cells. This is the scientists at the proliferation of know the process of HIV achieved a major breakthrough, the researchers will help to create a confrontation has resulted in the death of 25 million people of HIV vaccines. The results of the study published in the latest issue of "Science" magazine.

University of California, Davis USA and Mount Sinai School of Medicine researchers created a virus infection in HIV molecular cloning, and a protein insert their genetic code, the cloned virus exposure can be issued under the green ray. This allows scientists in the digital video equipment can be seen on these cells, and catch the T cells infected with HIV-infected cells and non-interactive way.

They pointed out that the infected cells when exposed to healthy cells, they will set up between the virological synapse is called a "bridge." In this way, researchers can be observed that the green fluorescent virus particles moving to the synapse and into the healthy cells.

The study revealed that the virus protein is gathered through the synapse and into the non-infected cells. Authors, University of California at Davis Center for Science and Technology Biophoton Chief Scientist Thomas? Husserl said that this discovery may explain why the development of an AIDS vaccine have been less than successful so far, research results will help to create a fight HIV and a new AIDS treatment. He said: "We know of such transfer mode more, the more we have the opportunity to find out how to block the spread of HIV and AIDS."

For decades, people have always believed that, HIV, mainly through the free flow of particles to the proliferation in the body, these particles can be attached to a cell's own up, take over the replication mechanism, and then produce many copies of their own. In 2004, scientists discovered, HIV in the transfer of cells through synaptic virus happened, but they can not understand why this process is so effective in the spread of the virus. Based on this, before the development of HIV vaccine efforts are concentrated in the activated immune system to identify and attack the free flow of virus protein.

The new video display, HIV can be transferred directly between the cells to circumvent the identification. Husserl said that they are developing can help the immune system to identify the format of synaptic protein containing virus vaccines and the necessary factor for the formation of synaptic target of antiviral drugs.

Thesis co-author, Mount Sinai School of Medicine, associate professor of medicine and epidemiology Benjamin? Chan, through the T cell synapse virus-T cell direct the transfer of HIV virus infection are an efficient way, are perhaps the most important mode of transmission.

The researchers plan further studies will focus on the transfer of these virus particles enter the new behavior of infected cells. (冯卫东)