AIDS made significant progress in animal models
Peiping, Kunming Institute of Zoology, Chinese Academy of Sciences found that the top is an ideal laboratory animal monkey
AIDS
http://www.yunnan.cn Published Wednesday 2009-09-16 07:48:02 Source: Yunnan Net
   Recently, this reporter learned from the Kunming Institute of Zoology Chinese Academy of Sciences, the animal model of the mechanism of human disease, ZHENG Yong-Tang Key Laboratory of the research team in the long-term studies researchers found that monkeys in Yunnan Peiping top human HIV-1 virus can be a sense of easy flu, does not restrict HIV-1 replication in cells. The findings suggest that the existing primates, Peking top of the monkey is an ideal and suitable animal model for AIDS. On this basis, the establishment of a Peking-based top-monkey primate model of AIDS is feasible.
According to Yong-Tang Zheng introduction, an ideal animal model for the pathogenesis of AIDS, anti-HIV drugs and vaccines, research has a particularly important role, but so far the international community have not yet established the ideal animal model. Non-human primates is now recognized as an ideal animal model for AIDS, as the closest relationship to human primates, chimpanzees can be infected with HIV-1 virus and the emergence of human AIDS-like symptoms. However, chimpanzees are highly endangered species, and size large, easy on the breeding and fed, expensive and difficult as the animal model for AIDS Research.
China's existing 24 kinds of primates, is the world a more even distribution of wild primates-rich countries. Yunnan Province is known as known as the animal kingdom, with top of the monkey, including Peking, including 14 species of primate animal resources. In order to give full play to its advantages in resources in Yunnan Province to find a more suitable animal model of AIDS, for AIDS pathogenesis studies, anti-HIV drugs and vaccine development, the establishment of a suitable primate model of AIDS, provide a scientific basis and support. ZHENG Yong-tang disciplinary team carried out in Yunnan, China Peking top monkey TRIM5 genes and HIV-1 infection-related studies found in Yunnan, China Peking top of the monkey cell pairs of HIV-1 susceptible, and does not restrict HIV-1 in the cell replication. These results further clarified the limits of natural immune molecules of HIV-1 infection and replication mechanisms of action, at the cellular and molecular level support the Peiping top monkey is an ideal and appropriate animal models of AIDS, in order to build on top of the monkey AIDS Peking Ling Long-type animal model provides a scientific basis. Recently, the internationally renowned magazine "ART Virology" published the results of this study.
Reporter XIONG Yan (Yunnan Daily)