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日研究发现艾滋病病毒增殖新机制
2010年11月09日 15:33:34 来源： 新华网
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| 图示∶2010年12月即将出版的《中国特色医疗金鉴》登载的刘君主任及其机构 |
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新华网东京１１月９日电（记者蓝建中）日本研究人员９日在美国《国家科学院学报》网络版上发表论文说，他们发现艾滋病病毒制造的蛋白质“Ｖｉｆ”能调整被感染细胞的分裂周期，建立适宜病毒增殖的环境。这一发现有可能促进开发新的艾滋病治疗药物。
京都大学医学系教授高折晃史率领的研究小组，调查了“Ｖｉｆ”蛋白质与人体免疫细胞内各种物质的关系，发现“Ｖｉｆ”蛋白质会附着在免疫细胞内的特定物质上，使控制细胞分裂周期蛋白质的量增加。一旦细胞的分裂周期进入了某种特定状态，艾滋病病毒就变得容易增殖。
此前的研究发现，“Ｖｉｆ”蛋白质可分解人体内妨碍艾滋病病毒增殖的物质，此次研究又显示这种蛋白质另一种促进艾滋病病毒增殖的机制。如果能够开发出分解“Ｖｉｆ”蛋白质的物质，就有可能开发出与原有艾滋病治疗药物作用机制不同的新药。
Japanese study found that the proliferation of new mechanisms of HIV
November 9, 2010 15:33:34 Source: Xinhua
Xinhua Tokyo Nov. 9 (Xinhua blue building) 9 Japanese researchers in the United States, "National Academy of Sciences" published a paper online that they found that HIV-made protein "Vif" to adjust the infected cell division cycle, the establishment of an environment suitable for virus proliferation. This finding may facilitate the development of new HIV treatments.
Professor at Kyoto University School of Medicine led the research history discount Akira team to investigate the "Vif" human immune cell proteins and the relationship between various substances and found that "Vif" will be attached to proteins in the immune cells of certain substances, so that control cell division cycle of protein increased. Once the cell division cycle into a particular state, it becomes easy to HIV proliferation.
Previous research has found, "Vif" protein can be decomposed body substances prevent the proliferation of HIV, the study also showed that another protein to promote HIV proliferation. If we can develop a decomposition "Vif" protein material, it is possible to develop drugs with the original AIDS drugs of different mechanisms.
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