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US-EU joint study group that found the vaccine can prevent HIV
2011-09-21 09:40:03 Source: Netease explore
Core Tip: It is understood, from the United States and Europe, a research group recently announced that they have AIDS research breakthrough has been made, they can be considered to have successfully found a vaccine against AIDS, which may be of human AIDS prevention and control work has brought new hope.
AIDS virus under a microscope.
Imperial College London: Boa Suo, led by Adriano from the U.S. and European scientists are working on HIV vaccines in-depth study.
NetEase reported September 21 to explore understood, from the United States and Europe, a research group recently announced that they have AIDS research breakthrough has been made, they can be considered to have successfully found a vaccine against AIDS, which may for human AIDS has brought new hope.
The study group said they found a way to prevent HIV destroys the immune system of the new method - if the virus is removed cholesterol from the cell membrane, then the virus can not attack the body's immune system to go . "It's like an army lost their weapons, but they are still the banner, so other forces will continue to identify their attack," presided over this study Adriano Imperial College London Boa Suo (Adriano Boasso), said that the project team now plans to study how the characteristics of the virus the possibility of developing targeted vaccine.
Typically, when the body is infected with HIV, the body's innate immune response system will immediately enter the state of defense. However, some researchers believe that HIV can cause the body's innate immune system overreaction, which will undoubtedly weaken the immune system in the next invasion of the virus defenses, this phenomenon in medicine is called "adaptive immune response." . In Boa Suo team study, researchers have successfully removed the virus in cell membrane cholesterol, and they found that this method can prevent the HIV virus to trigger "innate immune response" symptoms, but it also led to a more intense , by the immune cells "T cells" induced adaptive response.
Each year about 18 million people worldwide died of AIDS in 2009 alone, about 26 million people of HIV into torment among the world's approximately 3330 people living with HIV. The production company of AIDS antiviral only Gilead Bristol MyersSquibb, Merck, Pfizer and GlaxoSmithKline several large pharmaceutical giants. Over the years, including businesses, nonprofit organizations and governments around the world's scientists have been struggling to find effective vaccine against HIV, but most with little success.
In 2009, Thailand conducted a survey involving 16,000 volunteers, AIDS research, the first vaccination in patients with only a small part of the prevention and treatment of HIV have been due to prevention and treatment rate of only about 30%, so the researchers were not not re-studied. In May, the United States, an ongoing experimental HIV vaccine research team said that they developed a vaccine in monkeys suffering from AIDS more than a year happened a role to prevent the further spread of the virus, and this vaccine the future may be used to human AIDS prevention work.
Transmission of HIV There are many ways: sexual transmission, drug users sharing infected needles, breast milk or blood-borne, and so on, so for HIV infection, there is not a simple and effective method. In addition, the mutation rate of HIV is very fast, able to hide in the body's immune system, and those antibodies attack cells at any time.
Boa Suo said in the report: "HIV is very strange, it can escape the host's defense system, by causing excessive damage to the body's immune system response. It's like a car, driving for long periods in the low position, suddenly be replaced by high-end, the engine is likely to be suffocated, which is useless in many vaccines in the midst of the main reasons, most of the vaccine after identifying the intruder can make the appropriate adaptive response, but if the virus invasion by other means, these vaccines would be difficult to make the adaptive response of the. "
According to research personnel, and HIV infection among cells located in the cell membrane. And this membrane contains cholesterol in order to maintain its liquidity, it and certain types of cells interact. Typically, a subset of immune cells' plasma cells, dendritic cells (pDCs) "to quickly identify HIV, and by producing a product called" interferon "signal molecules for rapid response. These signaling molecules can help repair damaged immune system, but if the switching time is too long, it will damage the immune system to form. With the Johns Hopkins University, the University of Innsbruck University of Milan and the cooperation of scientists, Boa Suo's research group found that if HIV-cholesterol in cell membranes removed, it can not be activated pDCs cell . Therefore, in this environment, to coordinate the adaptive response of T cells can be more effective against the HIV virus.
Detailed report of the study published in the September 19, "Blood" magazine. (Source: "Daily Mail" compilation: Henrish article is a translation / translation / network for the translation of words and easy words to explore NetEase exclusive articles, please do not reprint without permission.)
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