艾滋病早期治疗是康复与延长30～60年生命的保障
“艾滋病28年来的发现、研究与治疗，从鸡尾酒到联合治疗，T细胞免疫重建意义重大；担负着挽救生命、保障健康与生存延长的重大使命。”康生丹四代Ⅱ类新药—三合皂甙发
最早提出免疫应答反应重启免疫，将CD4与T细胞纳入艾滋病治疗、研究与临床的统计进行科学的研究工作的，是康生丹2000年1月6日申报中国新药发明专利时的情景。
康生丹做为
每当确诊之后，患者大多依照CDC的要求在CD4低于200时才开始接受抗病毒〔俗称鸡尾酒〕治疗；目前发达国家ART指南推荐启动抗病毒治疗时机是CD4低于350开始，对某些特殊人群，如高HIV病毒量，合并HCV感染的，可以提前给药。但是有些人认为早启动治疗会最大限度降低HIV对免疫系统损害。去年美国和加拿大研究数据结论是当在CD4降到350前启动ART比降到350后启动，死亡风险降低70%，但研究没有说明如果在CD4高到500时启动会是什么结果。在加拿大举行的16届抗病毒和抗机会性感染大会上展示2个针对此的研究，但2个研究的结论相互冲突。北美的研究说明在CD4低于500时启动治疗比高于500时启动死亡风险增加60%。另一研究是欧洲和北美的合作观察数据，没有发现CD4高于400后启动治疗有任何益处。发现CD4在350-400间启动ART益处明显，但是在450-550间启动没有降低AIDS或死亡风险。大会指出这两研究缺乏严格可比性。前一个是观察死亡风险，后一个是观察AIDS和死亡风险。两个研究都没有针对非AIDS指征性疾病进行观察，而这些该是早期启动ART最担心的风险以及预防这些副作用的经济投入是否更值得。
著名杂志《柳叶刀》上文章，研究来自国际上14个大型临床点包括加拿大，欧洲和美国。观察共43，000名患者的死亡率和影响预后的因素。启动ART的时间分为1996-1999，2000-2002，2002-2005年间。临床研究数据表明，成功的ART治疗可以延长生存期到60岁以上：成功的ART治疗，如果是20岁开始，可以活到63岁，如果是35岁开始，可以活到67岁。如果是在CD4 200以上开始启动治疗，20岁者可以活到70岁，35岁者可以活到72岁。研究也表明在随着治疗的改进，ART的预期生存期在逐渐延长：1996-1999年预期生存期延长43年，到2002-2005年是近70年。静脉吸毒人员生存期要短20年。基线CD4低也是缩短生存期的因素。CD4在500时治疗HIV死亡风险可以忽略。女性总体比男性长。尽管如此，发现HIV阳性个体比HIV阴性的存活期短10年。还有非HIV相关的合并症。
CD４细胞是人体免疫系统中的一种重要免疫细胞，CD4 主要表达于辅助T（Th）细胞，是Th细胞TCR识别抗原的供受体，与MHCⅡ类分子的非多肽区结合，参与Th细胞TCR识别抗原的信号转导，CD4也是HIV的受体，由于艾滋病病毒攻击对象是CD４细胞，所以其检测结果对艾滋病治疗效果的判断和对患者免疫功能的判断有重要作用。正常成人的CD４细胞在每立方毫米500个到1600个，艾滋病病毒感染者的CD４细胞出现进行性或不规则性下降，标志着免疫系统受到严重损害，当CD４细胞小于每立方毫米200个时，可能发生多种机会性感染或肿瘤。艾滋病的感染原理：白细胞是杀灭外来细菌的人体卫士，它主要含CD4与CD8，CD4细胞起到“通风报信”的作用，CD8是吞噬细菌的细胞，当艾滋病毒进入人体后，它会绑架CD4细胞，使CD8细胞成为“瞎子+聋子”，然后艾滋病病毒便侵入白细胞内，将白细胞作为自己繁殖的温床。
康生丹主药中多种成分提升T细胞并识别正常T细胞、分别正常T细胞与HIV的结合，并使HIV结合之T细胞在药物作用下有机分离、剥离与脱落，HIV因失去蓿主营养供应而失去生存环境与生存生物活性，其失去活性之HIV则自行坏死、杀灭、调亡；同时，T细胞茁壮生长发挥特有细胞免疫作用，机体代谢则恢复正常。康生丹作用机理在于∶一，诱导激活免疫应答反应系统恢复免疫应答，使细胞免疫作用恢复，提升CD4；二∶抑制、杀灭、调亡HIV。其杀灭与抑制、调亡HIV作用主要依赖T细胞细胞免疫作用的恢复，细胞免疫识别功能的健全、识别与分离、剥落及脱落HIV结合点，使基因位点HIV结合失去生物活性，才真正发挥抗HIV的作用。这点也应征了中医之“正气存内，邪不可干；邪之所凑，其气必虚”的天人合一、阴阳合和与正本相固、禀赋核养等精髓理论。总而言之，康生丹治疗艾滋病是中医精华的发掘与实际应用的典范，临床上许多患者由开始的CD4很低而迅速提升至正常范围，也说明并验证了这一理论的存在价值；有关更深层次的作用，有待我们进一步的研究。
而在临床治疗中，首先要把握“感染”、“营养”与“免疫”三关，才是有效治疗艾滋病的关键，更是患者生命延长、最终康复的保证。
感染关是最先出现并自发病开始到晚期死亡都一直伴随治疗难题的问题。感染关的攻克，单纯的抗炎、抗病毒、抗真菌、抗霉菌、杀灭微生物寄生虫等都将使患者生命体征与生存周期不断降低；目前唯一的解决办法是中医的免疫激活、免疫调控、免疫诱导、免疫恢复。中医怎么样做到以上4点免疫的作用，康生丹在16年科研与6年的临床中，呈现可喜的现象；在千余例的患者治疗中，用药3个月大多得到并发症的控制；其控制并发症的原理在于特殊组分的免疫激活、免疫调控、免疫诱导、免疫恢复的实现；才使感染关得到了有效的控制与治疗；并且治疗后没有出现反复与反弹的现象。我们经过统计与实验有力的发现，药物缓慢作用于T淋巴细胞而提升CD4的机理，才是根本。
营养关更是患者死亡的又一难题。长期的抗感染用药严重的副作用首先就是营养的障碍；营养障碍表现于营养缺乏、营养不良与营养障碍三个方面。怎么样解决以上问题呢？营养药物的给药直观重要，而营养的调控更为重要；这个需要从饮食与食疗、精神三个思路去作用。更重要的也包括脾胃诱发疾病的治疗与康复。
免疫关是艾滋病患者终生困饶的难题，也是治疗与康复的关键，其重要性是首当其冲的，是其他治疗都无法更替的。只有科学、标准、合理的免疫治疗，才是康复艾滋病的保障。免疫系统对于人体的作用就是屏障作用，抵御疾病的屏障作用。免疫力的增强与减弱，取决于人体各个系统相互协调、周围环境与人体病程的各个变化；人体组织、脏器与功能的变化，协调于各个组织、脏器与功能的完善，免疫才至善至美，奏于至臻。
康生丹经历十三年科研与六年临床验证，证实了“感染”、“营养”与“免疫”三关的调摄，才有效治疗艾滋病；出现可控可调的科学作用。所以，我们建议患者∶一旦确诊立即治疗、迅速用药、全面防治，保障生命与有效康复。
综上所述∶艾滋病早期治疗是康复与控制并发症的关键；建议患者必须尽早治疗、以保障CD4达到正常或控制并发症而延长生命。
参考∶
艾滋病免疫重建的重要意义是挽救生命的根本http://www.zyynb.com/admin/Article_Show.asp?ArticleID=6029
艾滋病早期治疗必须严防“感染”、“营养”与“免疫”三关http://www.zyynb.com/admin/Article_Show.asp?ArticleID=4405
当今ART治疗可以预期生存期到70岁关于启动ART时机的研究http://www.zyynb.com/admin/Article_Show.asp?ArticleID=5230
终结艾滋病毒的“潜伏”
防治艾滋病中医大显身手 综述：中医药与时代同行
艾滋病和结核病双重感染之谜初步揭开
从食品植物研究开发的治疗艾滋病新药三合皂甙〔康生丹四代〕介绍
康生丹四代新药，化学名—三合皂甙分类引述
Early treatment of AIDS is the rehabilitation and extension of 30 ~ 60 years to protect the lives of
"AIDS 28 years ago the discovery, research and treatment, from cocktails to the combination therapy, T cell immune reconstitution of great significance; charged with saving lives, protect the health and survival of a major extension of the mission." Kang Sheng Dan Ⅱ type of four generations of new drugs - San saponin Mr. Liu Jun inventor with emotion to tell people so.
The first reaction of the immune response to the resumption of immunization, CD4 and T cells will be included in AIDS treatment, research and clinical statistics of scientific research work is Dan Kang Sheng January 6, 2000 declaration of the Chinese drug scene at the time of invention patents.
Kang Sheng Liu Dan as the outcome of AIDS research and media attention has been raised is the matter in 2003, more than six years ago. Six years, Kang Sheng Dan from the initial generation, the second generation to third-generation - Kang Sheng Dan particles, as well as the new fourth generation of chemical second-class drugs - saponin三合; experienced a lot of hard work exploration, and gradually found the chemical active ingredients -- three types of saponin, the HIV virus and its complications, such as starting with the reorganization of the immune response from immunization, the protection of T cell disorder, biological inhibition of human immunodeficiency virus drug to form plaques, which kill HIV; effective prevention science AIDS.
Liu Clinical Director since 2002 since the beginning of the treatment of AIDS patients, the practice of proof: AIDS patients with early treatment is the key to control the complications.
Every time after diagnosis, most patients in accordance with the requirements of CDC in the CD4 less than 200 when to start anti-virus, commonly known as cocktail〕 〔treatment; current ART guidelines recommended by the developed countries to start anti-viral CD4 treatment time is less than 350 to start, for some special groups, such as high HIV viral load, HCV infection of the merger can be administered in advance. But some people think that to start as early as the treatment of HIV will minimize damage to the immune system. The United States and Canada last year, research data and concluded that the CD4 dropped to 350 when to start ART ago after more than 350 down to start, 70 percent lower risk of death, but the researchers did not say if the CD4 high to 500 when they will be any results. In Canada, held the 16th anti-virus and anti-opportunistic infections to display the General Assembly two for this study, but the conclusions of two studies conflict with each other. Research in North America in activated CD4 less than 500 than 500 when the treatment start than the risk of death increased by 60%. Another study is the co-operation in Europe and North America observation data, there is no higher than the 400 found in CD4 after the startup of any benefits of treatment. CD4 between 350-400 was found to start ART in the obvious benefits, but did not start in between 450-550 to reduce the risk of AIDS or death. The General Assembly noted that the lack of strict comparability of the two studies. One is the observation before the risk of death, the latter is the observation of the risk of AIDS and death. Two studies are not indications for non-AIDS diseases were observed, which is the early start of the most worried about the risks of ART, as well as the prevention of these side effects are more worthy of economic input.
Well-known magazine "Lancet" on the article, researchers from 14 large-scale international clinical points, including Canada, Europe and the United States. A total of 43,000 patients observed mortality and prognostic factors. ART start time is divided into 1996-1999,2000-2002,2002-2005 years. Clinical research data shows that the success of ART treatment can extend survival to 60 years of age: the success of ART treatment, if it is the beginning of 20-year-old can live to 63 years old, if it is the beginning of 35-year-old can live to 67 years. If it is more than in CD4 200 started treatment, 20-year-old can live to 70 years old, 35-year-old can live to 72 years. Research also shows that improvements in treatment as, ART expected gradually to extend the survival time :1996-1999 period is expected to survive 43 years to 2002-2005, the last 70 years. Intravenous drug users in a shorter survival time 20 years. Low baseline CD4 is also shortened survival factor. CD4 at the treatment of HIV in 500 risk of death can be ignored. Women than men overall. In spite of this, found that HIV-positive individuals than HIV-negative short survival time for 10 years. Non-HIV-related complications.
CD4 cells are the body's immune system of an important immune cells, CD4 expression on supporting the main T (Th) cells, is the Th cells for TCR antigen recognition receptors, and MHC Ⅱ molecules of the non-binding peptides involved in Th cell TCR antigen recognition of the signal transduction, CD4 is the HIV receptor, as a result of HIV attacks CD4 cells is, so their test results to determine the effectiveness of AIDS treatment in patients with immune function and plays an important role in judgments. Normal adults in each of the CD4 cells mm3 500-1600, HIV-infected persons to carry out the CD4 cell decrease or irregular, marked by the serious damage to the immune system, when the CD4 cell is less than 200 per mm3 at may occur a number of opportunistic infections or tumors. Principles of HIV infection: is interleukin kill bacteria outside the human body guards, it mainly with CD4 and CD8, CD4 cells play the role of "tipped off" role, CD8 cells is phagocytosis of bacteria, when HIV enters the human body, it will be kidnapped CD4 cells to CD8 cells become "blind + deaf", and then they invaded leukocytes of HIV will be the WBC as a hotbed for breeding.
Dan Kang Sheng main drug in a variety of ingredients to enhance T cell and identify the normal T cells, T cells and normal, respectively, the combination of HIV and HIV combination of T cells in the separation of organic drugs, stripping and loss, HIV due to the loss of the main nutrition Medicago the supply of the living environment and the survival of the loss of biological activity, the loss of active necrosis of HIV on their own, killing, apoptosis; At the same time, T cells play a strong growth of the role of specific cell-mediated immunity, the return to a normal metabolism. Kang Sheng Dan mechanism is: First, activate the immune response induced by the restoration of the immune response system, so that the role of cellular immune recovery, enhancing CD4; II: inhibition, killing, apoptosis HIV. Its killing and suppression, the role of apoptosis in HIV relies mainly on the role of T cells in the recovery of cellular immunity, cellular immunity of the sound recognition, identification and separation, peeling off and falling HIV combination of points, so that HIV gene locus loss of biological activity combined with the real play the role of anti-HIV. This also apply for a Chinese medicine "keep righteousness, the evil can not be dry; together by evil, the gas will be empty," the harmony between man and nature, yin and yang of Hopewell and the original solid, such as the essence of endowment theory nuclear dependent. All in all, Dan Kang Sheng Chinese medicine treatment of AIDS is to explore the essence and the practical application of the model, many patients with clinically CD4 from the beginning of a very low and rapidly to the normal range, also shows that the theory and verify the existence of value; on the deeper the role of waiting for further study.
And in clinical treatment, we must first grasp the "infection", "nutrition" and "immune" three-clearance, is the key to effective treatment of AIDS, but also to extend the lives of patients, the ultimate guarantee of rehabilitation.
Clearance of infection and the first thing that shows from the beginning to the late onset of death have been problems with the issue of treatment. Infection related to capture, a simple anti-inflammatory, anti-virus, anti-fungal, anti-fungi, parasites and so on will kill micro-organisms in patients with vital signs and continue to lower the life cycle; the only solution is to TCM immune activation, immune control, immunization-induced immune to resume.怎么样做Chinese medicine for more than 4 points to the role of the immune, Kang Sheng Dan in 16 years research and 6 years of clinical in a good sign; in patients more than patients, the medication 3 months most of the control to be complications ; its control is the principle complication of immune activation of specific components of immune regulation, immune-induced immune recovery achieved; able to be an effective clearance of infection control and treatment; and repeatedly after treatment with no rebound phenomenon. We have a strong statistical and experimental discovery of the role of drug slow to upgrade to the T lymphocyte and the mechanism of CD4, is fundamental.
Nutrition related death is yet another problem. Long-term anti-infective drug use to serious side effects is the first obstacle to nutrition; nutrition nutritional deficiencies in the performance of barriers, malnutrition and nutrition three obstacles. How to solve the above problem? Nutrition intuitive important drug delivery, and nutrition is more important control; the need to diet and diet, mental approach to the role of the three. More importantly, including the spleen and stomach diseases induced by treatment and rehabilitation.
AIDS patients with immune related problems struggled for life, but also the key to treatment and rehabilitation, the importance of the first, the other can not change the treatment. Only science, standards, reasonable immunotherapy is to protect AIDS patients. The immune system is the role of the human barrier, the barrier to resist disease. Enhanced and weakened immunity, depending on the coordination between the various systems for the human body, the surrounding environment and the various changes in human disease; human tissues, organs and functions of the changes in the coordination of the various organizations, organs and functions of the perfect, perfect before the immune to the United States, playing to reach the.
Kang Sheng Dan six years experience of thirteen years of scientific research and clinical testing, confirmed the "infection", "nutrition" and "immune" three-tone photo only effective treatment for AIDS; emerging science and the role of controllable adjustable. Therefore, we recommend that patients: Once diagnosed immediate treatment, the rapid use, comprehensive prevention and control, protection of life and effective rehabilitation.
To sum up: the early treatment of AIDS patients and control of complications is the key; the proposed treatment of patients as soon as possible in order to protect normal CD4 or control of complications and prolong life.
Reference:
AIDS, the importance of immune reconstitution is the fundamental life-saving
http://www.zyynb.com/admin/Article_Show.asp?ArticleID=6029
Early treatment of AIDS must be to prevent "infected", "nutrition" and "immune" three -
http://www.zyynb.com/admin/Article_Show.asp?ArticleID=4405
ART treatment today can expect survival to 70-year-old on the start time of the study ART
http://www.zyynb.com/admin/Article_Show.asp?ArticleID=5230
The end of HIV "latent"
To show their talents to fight AIDS Chinese medicine Roundup: Chinese medicine with the times
Scientists study found that AIDS virus in the human body to hide
AIDS and tuberculosis infection in the mystery of double the initial kick
From food of plant research and development of new drugs to treat AIDS三合saponins Dan Kang Sheng 〔〕 introduced four generations
Dan Kang Sheng four generations of new drugs, chemical name - San categories quoted saponins
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